| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prothrombin |
|---|
| Ligand | BDBM50076953 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_208867 (CHEMBL808333) |
|---|
| IC50 | 260±n/a nM |
|---|
| Citation |  Adang, AE; Peters, AM; Gerritsma, S; de Zwart, E; Veeneman, G Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety. Bioorg Med Chem Lett9:1227-32 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prothrombin |
|---|
| Name: | Prothrombin |
|---|
| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 70029.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00734 |
|---|
| Residue: | 622 |
|---|
| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
|---|
| BDBM50076953 |
|---|
| n/a |
|---|
| Name | BDBM50076953 |
|---|
| Synonyms: | (R)-1-(3,3-Diphenyl-propionyl)-pyrrolidine-2-carboxylic acid ((S)-2-benzylcarbamoyl-2-oxo-1-piperidin-4-ylmethyl-ethyl)-amide | CHEMBL283570 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H42N4O4 |
|---|
| Mol. Mass. | 594.7431 |
|---|
| SMILES | O=C(CC(c1ccccc1)c1ccccc1)N1CCC[C@@H]1C(=O)N[C@@H](CC1CCNCC1)C(=O)C(=O)NCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
