| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50076994 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101758 |
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| Ki | 2.3±n/a nM |
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| Citation |  Cherney, RJ; Wang, L; Meyer, DT; Xue, CB; Arner, EC; Copeland, RA; Covington, MB; Hardman, KD; Wasserman, ZR; Jaffee, BD; Decicco, CP Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production. Bioorg Med Chem Lett9:1279-84 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50076994 |
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| n/a |
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| Name | BDBM50076994 |
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| Synonyms: | (2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7diaza-cyclotridecane-2,11-dicarboxylic acid 11-hydroxyamide 2-methylamide | CHEMBL277658 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H44N4O6S |
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| Mol. Mass. | 552.726 |
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| SMILES | CNC(=O)[C@@H]1CCCCN(CCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)S(=O)(=O)c1c(C)cc(C)cc1C |
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| Structure | 
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