| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Trypanothione reductase |
|---|
| Ligand | BDBM50093211 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_211803 |
|---|
| Ki | 850±n/a nM |
|---|
| Citation |  Chitkul, B; Bradley, M Optimising inhibitors of trypanothione reductase using solid-phase chemistry. Bioorg Med Chem Lett10:2367-9 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Trypanothione reductase |
|---|
| Name: | Trypanothione reductase |
|---|
| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
|---|
| Type: | Homodimer; oxidoreductase |
|---|
| Mol. Mass.: | 53868.26 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | n/a |
|---|
| Residue: | 492 |
|---|
| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
|
|
|
|---|
| BDBM50093211 |
|---|
| n/a |
|---|
| Name | BDBM50093211 |
|---|
| Synonyms: | CHEMBL308396 | Spermine derivative |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H27F6N5O4 |
|---|
| Mol. Mass. | 623.5462 |
|---|
| SMILES | Oc1c(cnc2cc(ccc12)C(F)(F)F)C(=O)NCCCCNCCCNC(=O)c1cnc2cc(ccc2c1O)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
