| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50087289 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208206 |
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| IC50 | >1000000±n/a nM |
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| Citation |  Manfredini, S; Baraldi, PG; Durini, E; Porcu, L; Angusti, A; Vertuani, S; Solaroli, N; De Clercq, E; Karlsson, A; Balzarini, J Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors. Bioorg Med Chem Lett11:1329-32 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_VZVD | TK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37819.99 |
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| Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
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| Description: | ChEMBL_444706 |
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| Residue: | 341 |
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| Sequence: | MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
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| BDBM50087289 |
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| n/a |
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| Name | BDBM50087289 |
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| Synonyms: | 1-beta-D-Arabinofuranosylcytosine | 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone | 4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one | CHEMBL803 | CYTARABINE |
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| Type | Small organic molecule |
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| Emp. Form. | C9H13N3O5 |
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| Mol. Mass. | 243.2166 |
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| SMILES | Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1 |r| |
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| Structure | 
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