| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine deaminase |
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| Ligand | BDBM50106015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_30789 |
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| Ki | 152000±n/a nM |
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| Citation |  Wang, L; Hosmane, RS A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine. Bioorg Med Chem Lett11:2893-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Adenosine deaminase |
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| Name: | Adenosine deaminase |
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| Synonyms: | ADA | ADA_BOVIN | Adenosine aminohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 40910.44 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 363 |
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| Sequence: | MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPE
FLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAI
DLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGY
HTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIF
KSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAE
QCL
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|
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| BDBM50106015 |
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| n/a |
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| Name | BDBM50106015 |
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| Synonyms: | 2-(4,6-Diamino-8-imino-8,8a-dihydro-3aH-1,3,5,7-tetraaza-azulen-1-ylmethoxy)-ethanol; compound with trifluoro-methanesulfonic acid | CHEMBL95745 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H15N7O2 |
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| Mol. Mass. | 253.2611 |
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| SMILES | Nc1nc(N)c2NCN(COCCO)c2c(=N)n1 |
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| Structure | 
|
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