| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50096659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_140633 |
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| IC50 | 3843±n/a nM |
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| Citation |  Corbett, JW; Kresge, KJ; Pan, S; Cordova, BC; Klabe, RM; Rodgers, JD; Erickson-Viitanen, SK Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase. Bioorg Med Chem Lett11:309-12 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50096659 |
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| n/a |
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| Name | BDBM50096659 |
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| Synonyms: | 3-[3-Cyclopropyl-1-(3,5-dimethoxy-benzyloxy)-1-trifluoromethyl-prop-2-ynyl]-5-ethyl-6-methyl-1H-pyridin-2-one | CHEMBL107899 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26F3NO4 |
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| Mol. Mass. | 449.4627 |
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| SMILES | CCc1cc(c(=O)[nH]c1C)C(OCc1cc(OC)cc(OC)c1)(C#CC1CC1)C(F)(F)F |
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| Structure | 
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