Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50098193 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_147168 |
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Ki | 2.4±n/a nM |
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Citation | Clayson, J; Jales, A; Tyacke, RJ; Hudson, AL; Nutt, DJ; Lewis, JW; Husbands, SM Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole. Bioorg Med Chem Lett11:939-43 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50098193 |
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n/a |
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Name | BDBM50098193 |
Synonyms: | 22-cyclopropylmethyl-2-propylamino-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaen-16-ol | CHEMBL368600 |
Type | Small organic molecule |
Emp. Form. | C29H33N3O2 |
Mol. Mass. | 455.5912 |
SMILES | CCCN[C@]12Cc3c([nH]c4ccccc34)[C@@H]3Oc4c5c(CC1N(CC1CC1)CCC235)ccc4O |TLB:17:18:4:22.28.27,THB:23:22:4:18.19.20,3:4:18.19.20:22.28.27| |
Structure |
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