Reaction Details |
| Report a problem with these data |
Target | Thymidine phosphorylase |
---|
Ligand | BDBM50121756 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_208388 |
---|
Ki | 64300±n/a nM |
---|
Citation | Price, ML; Guida, WC; Jackson, TE; Nydick, JA; Gladstone, PL; Juarez, JC; Doñate, F; Ternansky, RJ Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model. Bioorg Med Chem Lett13:107-10 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thymidine phosphorylase |
---|
Name: | Thymidine phosphorylase |
Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 49948.87 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
Residue: | 482 |
Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
|
|
|
BDBM50121756 |
---|
n/a |
---|
Name | BDBM50121756 |
Synonyms: | (benzylamino)[(2,4-dioxo-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidin-7-yl)amino]methaniminium |
Type | Small organic molecule |
Emp. Form. | C14H14N5O2S |
Mol. Mass. | 316.358 |
SMILES | NC(NCc1ccccc1)=[NH+]c1csc2c1[nH]c(=O)[nH]c2=O |w:10.11| |
Structure |
|