| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 1B1 |
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| Ligand | BDBM50131044 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_51378 |
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| IC50 | 69±n/a nM |
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| Citation |  Don, MJ; Lewis, DF; Wang, SY; Tsai, MW; Ueng, YF Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1. Bioorg Med Chem Lett13:2535-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 1B1 |
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| Name: | Cytochrome P450 1B1 |
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| Synonyms: | CP1B1_HUMAN | CYP1B1 | CYPIB1 | Cytochrome P450 1B1 (CYP1B1) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60861.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1474523 |
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| Residue: | 543 |
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| Sequence: | MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
TCQ
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| BDBM50131044 |
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| n/a |
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| Name | BDBM50131044 |
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| Synonyms: | 13H-Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5-one | CHEMBL413956 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H11N3O |
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| Mol. Mass. | 285.2994 |
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| SMILES | O=c1c2ccccc2[nH]c2c3nc4ccccc4c3ccn12 |
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| Structure | 
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