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TargetThymidylate kinase
LigandBDBM50118627
Substrate/Competitorn/a
Meas. Tech.ChEBML_208218
Ki 45000±n/a nM
Citation Vanheusden VVan Rompaey PMunier-Lehmann HPochet SHerdewijn PVan Calenbergh S Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorg Med Chem Lett 13:3045-8 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidylate kinase
Name:Thymidylate kinase
Synonyms:TMPK | Thymidine monophosphate kinase | dTMP kinase
Type:PROTEIN
Mol. Mass.:22636.29
Organism:Mycobacterium tuberculosis
Description:ChEMBL_208218
Residue:214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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  Blast E-value cutoff:
BDBM50118627
n/a
NameBDBM50118627
Synonyms:(R)-1-((R)-4-Amino-3-hydroxy-5-methylphosphate-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | Phosphoric acid mono-[3-amino-4-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester
TypeSmall organic molecule
Emp. Form.C10H14N3O8P
Mol. Mass.335.2083
SMILESCc1cn([C@@H]2O[C@H](COP([O-])([O-])=O)[C@@H](N)[C@H]2O)c(=O)[nH]c1=O
Structure
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