| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM50366878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_206952 (CHEMBL814840) |
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| IC50 | 570000±n/a nM |
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| Citation |  Dekker, FJ; de Mol, NJ; Fischer, MJ; Liskamp, RM Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand. Bioorg Med Chem Lett13:1241-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM50366878 |
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| n/a |
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| Name | BDBM50366878 |
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| Synonyms: | CHEMBL1793841 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H40N5O12P |
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| Mol. Mass. | 645.5959 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)[C@@H](C)O)C(N)=O |
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| Structure | 
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