| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM50047342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_157829 |
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| IC50 | 28700±n/a nM |
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| Citation |  Jahng, Y; Zhao, LX; Moon, YS; Basnet, A; Kim, EK; Chang, HW; Ju, HK; Jeong, TC; Lee, ES Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities. Bioorg Med Chem Lett14:2559-62 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10 |
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| Type: | Protein |
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| Mol. Mass.: | 69020.39 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q05769 |
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| Residue: | 604 |
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| Sequence: | MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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| BDBM50047342 |
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| n/a |
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| Name | BDBM50047342 |
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| Synonyms: | (E)-3-Phenyl-1-pyridin-2-yl-propenone | 3-Phenyl-1-pyridin-2-yl-propenone | CHEMBL284742 | cid_5354119 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11NO |
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| Mol. Mass. | 209.2432 |
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| SMILES | O=C(\C=C\c1ccccc1)c1ccccn1 |
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| Structure | 
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