Reaction Details |
| Report a problem with these data |
Target | Interstitial collagenase |
---|
Ligand | BDBM8466 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_106300 (CHEMBL714556) |
---|
IC50 | 170±n/a nM |
---|
Citation | Reiter, LA; Robinson, RP; McClure, KF; Jones, CS; Reese, MR; Mitchell, PG; Otterness, IG; Bliven, ML; Liras, J; Cortina, SR; Donahue, KM; Eskra, JD; Griffiths, RJ; Lame, ME; Lopez-Anaya, A; Martinelli, GJ; McGahee, SM; Yocum, SA; Lopresti-Morrow, LL; Tobiassen, LM; Vaughn-Bowser, ML Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett14:3389-95 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Interstitial collagenase |
---|
Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
BDBM8466 |
---|
n/a |
---|
Name | BDBM8466 |
Synonyms: | (2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3-methylbutanamide | CHEMBL114272 | hydroxamate analogue 2 |
Type | Small organic molecule |
Emp. Form. | C12H18N2O5S |
Mol. Mass. | 302.347 |
SMILES | COc1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(=O)NO |r| |
Structure |
|