| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50148215 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106300 (CHEMBL714556) |
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| IC50 | 3800±n/a nM |
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| Citation |  Reiter, LA; Robinson, RP; McClure, KF; Jones, CS; Reese, MR; Mitchell, PG; Otterness, IG; Bliven, ML; Liras, J; Cortina, SR; Donahue, KM; Eskra, JD; Griffiths, RJ; Lame, ME; Lopez-Anaya, A; Martinelli, GJ; McGahee, SM; Yocum, SA; Lopresti-Morrow, LL; Tobiassen, LM; Vaughn-Bowser, ML Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett14:3389-95 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50148215 |
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| n/a |
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| Name | BDBM50148215 |
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| Synonyms: | 4-[4-(4-Fluoro-pyridin-2-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | CHEMBL113705 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18FN3O6S |
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| Mol. Mass. | 411.405 |
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| SMILES | ONC(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Oc2cc(F)ccn2)cc1 |
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| Structure | 
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