| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50142711 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_41188 |
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| Ki | 29000±n/a nM |
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| Citation |  Tsang, WY; Dhanda, A; Schofield, CJ; Frère, JM; Galleni, M; Page, MI The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives. Bioorg Med Chem Lett14:1737-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ENTCL | ampC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41306.67 |
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| Organism: | Enterobacter cloacae |
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| Description: | ChEMBL_40258 |
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| Residue: | 381 |
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| Sequence: | MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHY
YTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQ
WQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGA
LAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQA
YGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEA
NTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLA
NTSYPNPARVEAAYHILEALQ
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| BDBM50142711 |
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| n/a |
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| Name | BDBM50142711 |
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| Synonyms: | (R)-5-Methyl-2-(6-oxo-5-phenyl-3-thioxo-piperazin-2-yl)-3,6-dihydro-2H-[1,3]thiazine-4-carboxylic acid anion |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N3O3S2 |
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| Mol. Mass. | 362.447 |
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| SMILES | CC1CS[C@@H](NC1C([O-])=O)c1nc(O)c([nH]c1=S)-c1ccccc1 |
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| Structure | 
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