| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM19130 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_88030 |
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| IC50 | 40±n/a nM |
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| Citation |  Nishino, N; Yoshikawa, D; Watanabe, LA; Kato, T; Jose, B; Komatsu, Y; Sumida, Y; Yoshida, M Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. Bioorg Med Chem Lett14:2427-31 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HDAC8_MOUSE | Hdac8 | Histone deacetylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41767.71 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_88030 |
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| Residue: | 377 |
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| Sequence: | MEMPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDCPATEGIFDYAAAIGGGTI
TAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKY
YHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYVLQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM19130 |
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| n/a |
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| Name | BDBM19130 |
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| Synonyms: | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide | CHEMBL99 | TSA | Trichostatin A (TSA) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22N2O3 |
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| Mol. Mass. | 302.3682 |
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| SMILES | CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1| |
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| Structure | 
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