| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 5 |
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| Ligand | BDBM50366962 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_87889 |
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| IC50 | 74±n/a nM |
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| Citation |  Nishino, N; Yoshikawa, D; Watanabe, LA; Kato, T; Jose, B; Komatsu, Y; Sumida, Y; Yoshida, M Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. Bioorg Med Chem Lett14:2427-31 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 5 |
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| Name: | Histone deacetylase 5 |
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| Synonyms: | HD5 | HDAC5_MOUSE | Hdac5 | Histone deacetylase | Histone deacetylase mHDA1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 120932.97 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_87889 |
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| Residue: | 1113 |
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| Sequence: | MNSPNESDGMSGREPSLGILPRTPLHSIPVAVEVKPVLPGAMPSSMGGGGGGSPSPVELR
GALAGPMDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ
QEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQE
FLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLLGPYDSR
DDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGTGPGVSS
VCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMIPQHRALPLDSSPNQFSLYTSPSL
PNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLG
VALEGDTSPHGHASLLQHVCSWTGRQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRH
RPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPE
ETEEELTEQQEALLGEGALTIPREGSTESESTQEDLEEEEEEEEEEEEDCIQVKDEDGES
GPDEGPDLEESSAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKS
PTDQPTVVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLGKCER
IRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSD
TVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVA
ITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEE
VGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEGH
LSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQP
LDEAVLQQKPSVNAVATLEKVIEIQSKHWSCVQRFAAGLGCSLREAQTGEKEEAETVSAM
ALLSVGAEQAQAVATQEHSPRPAEEPMEQEPAL
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| BDBM50366962 |
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| n/a |
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| Name | BDBM50366962 |
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| Synonyms: | CHEMBL1790586 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H45N5O7 |
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| Mol. Mass. | 587.7076 |
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| SMILES | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](CCCCCN(O)C=O)NC(=O)[C@H]2CCCCN2C1=O |
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| Structure | 
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