| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50010932 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54607 |
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| Ki | 0.002100±n/a nM |
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| Citation |  DeGraw, JI; Brown, VH; Tagawa, H; Kisliuk, RL; Gaumont, Y; Sirotnak, FM Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin. J Med Chem25:1227-30 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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| BDBM50010932 |
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| n/a |
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| Name | BDBM50010932 |
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| Synonyms: | (10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid(10-DAM) | CHEMBL11191 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N7O5 |
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| Mol. Mass. | 439.4246 |
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| SMILES | Nc1nc(N)c2nc(CCc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cnc2n1 |
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| Structure | 
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