| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Angiotensin-converting enzyme |
|---|
| Ligand | BDBM50027634 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_35222 (CHEMBL884028) |
|---|
| IC50 | 74±n/a nM |
|---|
| Citation |  Kim, DH; Guinosso, CJ; Buzby, GC; Herbst, DR; McCaully, RJ; Wicks, TC; Wendt, RL (Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents. J Med Chem26:394-403 (1983) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Angiotensin-converting enzyme |
|---|
| Name: | Angiotensin-converting enzyme |
|---|
| Synonyms: | ACE_RAT | Ace | Angiotensin-converting enzyme | Dcp1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 150907.81 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_35219 |
|---|
| Residue: | 1313 |
|---|
| Sequence: | MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGNFSADEAGAQLFADSYN
SSAEVVMFQSTAASWAHDTNITEENARLQEEAALINQEFAEVWGKKAKELYESIWQNFTD
QKLRRIIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSLDPELTN
ILASSRNYAKVLFAWEGWHDAVGIPLRPLYQDFTALSNEAYRQDGFSDTGAYWRSWYESP
SFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIY
DMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADG
REVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANP
GFHEAIGDVLALSVSTPAHLHKIGLLDRVANDIESDINYLLKMALEKIAFLPFGYLVDQW
RWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNETHFDAGAKFHIPSVTPYIRYFVSF
VLQFQFHQALCKEAGHQGPLHQCDIYQSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDAL
DASALMEYFQPVSQWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVE
EYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQN
STIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVCYTNGTCLSLEPDLTNIM
ATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDL
EQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDL
VAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGRE
VVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGF
HEAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRW
RVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFII
QFQFHEALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSA
SAIMNYFKPLTEWLVTENRRHGETLGWPEYTWTPNTARAEGSLPESSRVNFLGMYLEPQQ
ARVGQWVLLFLGVALLVATVGLAHRLYNIHNHHSLRRPHRGPQFGSEVELRHS
|
|
|
|---|
| BDBM50027634 |
|---|
| n/a |
|---|
| Name | BDBM50027634 |
|---|
| Synonyms: | 1-(2-Mercapto-propionyl)-2,3-dihydro-1H-indole-2-carboxylic acid | CHEMBL336384 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H13NO3S |
|---|
| Mol. Mass. | 251.302 |
|---|
| SMILES | CC(S)C(=O)N1C(Cc2ccccc12)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
