| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter |
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| Ligand | BDBM50224808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68600 (CHEMBL681134) |
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| IC50 | >500000±n/a nM |
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| Citation |  Krogsgaard-Larsen, P; Mikkelsen, H; Jacobsen, P; Falch, E; Curtis, DR; Peet, MJ; Leah, JD 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J Med Chem26:895-900 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter |
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| Name: | Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter |
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| Synonyms: | GABA transporter |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 177939 |
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| Components: | This complex has 4 components. |
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| Component 1 |
| Name: | Sodium- and chloride-dependent GABA transporter 3 |
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| Synonyms: | Gabt3 | Gat-3 | Gat-b | S6A11_RAT | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Solute carrier family 6 member 11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69948.77 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105007 |
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| Residue: | 627 |
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| Sequence: | MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAG
EIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRV
CPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQK
LNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWK
GTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQ
IFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGV
PIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM
YPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECV
CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYT
YPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPR
MVTVNDCEAKVKGDGTISAITEKETHF
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| Component 2 |
| Name: | Sodium- and chloride-dependent GABA transporter 2 |
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| Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | S6A13_RAT | Slc6a13 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68261.89 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_70051 |
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| Residue: | 602 |
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| Sequence: | MDNRVSGTTSNGETKPVCPVMEKVEEDGTLEREQWTNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRKICPIFEGIGYASQM
IVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENAT
SPVIEFWERRVLKISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREILI
LIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGASRFYDNI
EDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMVCIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKSQPELTSPATPMTSLLRLTELES
NC
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| Component 3 |
| Name: | Sodium- and chloride-dependent GABA transporter 1 |
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| Synonyms: | GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67006.26 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1472611 |
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| Residue: | 599 |
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| Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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| Component 4 |
| Name: | Sodium- and chloride-dependent betaine transporter |
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| Synonyms: | Na(+)/Cl(-) betaine/GABA transporter | S6A12_RAT | Slc6a12 | Sodium- and chloride-dependent betaine transporter | Solute carrier family 6 member 12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69749.57 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105007 |
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| Residue: | 614 |
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| Sequence: | MDRKVTVHEDGCPVVSWVPEEGEMMDQKDKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGM
ASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASY
SENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY
FTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRKRGR
RELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADR
FYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYIYPSWGYSIGW
LLAFSSMACVPLFIIITLLKTQGSFKKRLQRLITPDPSLPQPGRRSPQDGSSAQNCSTSP
VKQELIAWEKETHL
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| BDBM50224808 |
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| n/a |
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| Name | BDBM50224808 |
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| Synonyms: | CHEMBL309689 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H10N2O2 |
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| Mol. Mass. | 154.1665 |
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| SMILES | Oc1noc2CCNCCc12 |
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| Structure | 
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