| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50020967 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28965 (CHEMBL640605) |
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| IC50 | 1.6±n/a nM |
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| Citation |  Hamilton, HW; Ortwine, DF; Worth, DF; Badger, EW; Bristol, JA; Bruns, RF; Haleen, SJ; Steffen, RP Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application. J Med Chem28:1071-9 (1985) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36602.99 |
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| Organism: | BOVINE |
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| Description: | ADENOSINE 0 BOVINE::P28190 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPVDEDAPAERPDD
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| BDBM50020967 |
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| n/a |
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| Name | BDBM50020967 |
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| Synonyms: | 4-(1,3-Diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-N-(3-dimethylamino-propyl)-benzenesulfonamide | CHEMBL10913 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28N6O4S |
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| Mol. Mass. | 448.539 |
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| SMILES | CCn1c2nc([nH]c2c(=O)n(CC)c1=O)-c1ccc(cc1)S(=O)(=O)NCCCN(C)C |
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| Structure | 
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