| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50022178 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_31926 (CHEMBL642969) |
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| IC50 | 62000±n/a nM |
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| Citation |  Brubaker, AN; DeRuiter, J; Whitmer, WL Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones. J Med Chem29:1094-9 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50022178 |
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| n/a |
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| Name | BDBM50022178 |
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| Synonyms: | 4-Methyl-7-hydroxycoumarin | 4-methylumbelliferone | 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran | 7-Hydroxy-4-methyl-2-oxo-3-chromene | 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one | 7-Hydroxy-4-methyl-2H-2-one (1) | 7-Hydroxy-4-methylcoumarin | 7-hydroxy-4-methyl-2H-chromen-2-one | CHEMBL12208 | Coumarin derivative, 3b | Imecromone | beta-Methylumbelliferone | cid_5280567 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8O3 |
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| Mol. Mass. | 176.1687 |
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| SMILES | Cc1cc(=O)oc2cc(O)ccc12 |
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| Structure | 
|
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