| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50024453 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_3912 (CHEMBL619916) |
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| IC50 | 55000±n/a nM |
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| Citation |  Summers, JB; Mazdiyasni, H; Holms, JH; Ratajczyk, JD; Dyer, RD; Carter, GW Hydroxamic acid inhibitors of 5-lipoxygenase. J Med Chem30:574-80 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78082.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1432947 |
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| Residue: | 673 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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| BDBM50024453 |
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| n/a |
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| Name | BDBM50024453 |
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| Synonyms: | CHEMBL277539 | Icosa-8,11,14-trienoic acid hydroxyamide | Icosa-8,11,14-trienoic acid hydroxyamide(5,6-DHA) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H35NO2 |
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| Mol. Mass. | 321.4974 |
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| SMILES | CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(=O)NO |
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| Structure | 
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