| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM50014815 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_51214 |
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| EC50 | 71±n/a nM |
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| Citation |  Taylor, HM; Jones, CD; Davenport, JD; Hirsch, KS; Kress, TJ; Weaver, D Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines. J Med Chem30:1359-65 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58418.09 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_51211 |
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| Residue: | 508 |
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| Sequence: | MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLI
SHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKR
GLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTD
NSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWL
YRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCI
LEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFI
NESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEK
NVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLH
LDEDSPIVEIIFRHIFNTPFLQCLYISL
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|
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| BDBM50014815 |
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| n/a |
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| Name | BDBM50014815 |
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| Synonyms: | Bis-(4-chloro-phenyl)-pyrimidin-5-yl-methanol | CHEMBL29904 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Cl2N2O |
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| Mol. Mass. | 331.196 |
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| SMILES | OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1 |
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| Structure | 
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