| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Renin |
|---|
| Ligand | BDBM50022858 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_196287 (CHEMBL806641) |
|---|
| IC50 | 370000±n/a nM |
|---|
| Citation |  Sawyer, TK; Pals, DT; Mao, B; Staples, DJ; de Vaux, AE; Maggiora, LL; Affholter, JA; Kati, W; Duchamp, D; Hester, JB Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions. J Med Chem31:18-30 (1988) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Renin |
|---|
| Name: | Renin |
|---|
| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45058.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 406 |
|---|
| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
|---|
| BDBM50022858 |
|---|
| n/a |
|---|
| Name | BDBM50022858 |
|---|
| Synonyms: | CHEMBL103365 | His-Sta-Leu-Phe-NH2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H45N7O5 |
|---|
| Mol. Mass. | 571.7115 |
|---|
| SMILES | CC(C)CC(NC(=O)[C@@H](N)Cc1cnc[nH]1)C(O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
