| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50225889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153332 (CHEMBL760484) |
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| Ki | 110000±n/a nM |
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| Citation |  Sanghvi, YS; Hanna, NB; Larson, SB; Fujitaki, JM; Willis, RC; Smith, RA; Robins, RK; Revankar, GR Synthesis and evaluation of 5-amino-1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase. J Med Chem31:330-5 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50225889 |
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| n/a |
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| Name | BDBM50225889 |
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| Synonyms: | CHEMBL3144008 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12N4O5 |
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| Mol. Mass. | 268.2261 |
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| SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)C1=NNC2C1=NC=NC2=O |r,c:17,t:10,15| |
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| Structure | 
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