| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM50014809 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_51212 |
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| EC50 | 11±n/a nM |
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| Citation |  Jones, CD; Winter, MA; Hirsch, KS; Stamm, N; Taylor, HM; Holden, HE; Davenport, JD; Krumkalns, EV; Suhr, RG Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups. J Med Chem33:416-29 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58418.09 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_51211 |
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| Residue: | 508 |
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| Sequence: | MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLI
SHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKR
GLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTD
NSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWL
YRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCI
LEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFI
NESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEK
NVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLH
LDEDSPIVEIIFRHIFNTPFLQCLYISL
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| BDBM50014809 |
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| n/a |
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| Name | BDBM50014809 |
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| Synonyms: | 1-[(4-Chloro-phenyl)-(4-trifluoromethyl-phenyl)-methyl]-1H-imidazole | CHEMBL135595 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClF3N2 |
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| Mol. Mass. | 336.739 |
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| SMILES | FC(F)(F)c1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnc1 |
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| Structure | 
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