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TargetNorepinephrine transporter
LigandBDBM50021879
Substrate/Competitorn/a
Meas. Tech.ChEBML_131452
Ki 0.680000±n/a nM
Citation Maryanoff BEVaught JLShank RPMcComsey DFCostanzo MJNortey SO Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J Med Chem 33:2793-7 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Norepinephrine transporter
Name:Norepinephrine transporter
Synonyms:Sodium-dependent noradrenaline transporter
Type:Enzyme Catalytic Domain
Mol. Mass.:69260.85
Organism:MOUSE
Description:Norepinephrine transporter 0 MOUSE::O55192
Residue:617
Sequence:
MLLARMNPQVQPELGGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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  Blast E-value cutoff:
BDBM50021879
n/a
NameBDBM50021879
Synonyms:6-(4-Chloro-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline;HBr | CHEMBL285506
TypeSmall organic molecule
Emp. Form.C18H18ClN
Mol. Mass.283.795
SMILESClc1ccc(cc1)[C@@H]1CN2CCC[C@@H]2c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: