| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50013960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_201137 (CHEMBL803878) |
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| IC50 | 302±n/a nM |
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| Citation |  de Costa, BR; Rice, KC; Bowen, WD; Thurkauf, A; Rothman, RB; Band, L; Jacobson, AE; Radesca, L; Contreras, PC; Gray, NM Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes. J Med Chem33:3100-10 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM50013960 |
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| n/a |
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| Name | BDBM50013960 |
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| Synonyms: | N-Methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-2-(3,4,5-trimethoxy-phenyl)-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H34N2O4 |
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| Mol. Mass. | 390.5164 |
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| SMILES | COc1cc(CC(=O)N(C)C2CCCC[C@@H]2N2CCCC2)cc(OC)c1OC |
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| Structure | 
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