| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium-transporting ATPase alpha chain 1/subunit beta |
|---|
| Ligand | BDBM50367961 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_75907 (CHEMBL686427) |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  LaMattina, JL; McCarthy, PA; Reiter, LA; Holt, WF; Yeh, LA Antiulcer agents. 4-substituted 2-guanidinothiazoles: reversible, competitive, and selective inhibitors of gastric H+,K(+)-ATPase. J Med Chem33:543-52 (1990) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium-transporting ATPase alpha chain 1/subunit beta |
|---|
| Name: | Potassium-transporting ATPase alpha chain 1/subunit beta |
|---|
| Synonyms: | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1/beta chain |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 71495 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Potassium-transporting ATPase alpha chain 1 |
|---|
| Synonyms: | ATP4A | ATP4A_HUMAN | Gastric H(+)/K(+) ATPase subunit alpha | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 114109.05 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | EBI_82 |
|---|
| Residue: | 1035 |
|---|
| Sequence: | MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVA
ELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAA
ICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQA
TVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSP
ECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIE
HFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAK
RLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQ
TFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMG
YRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELP
LDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLV
SMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLR
VPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLG
AIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIF
DNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAES
DIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQ
WEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGF
FRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLG
VRCCPGSWWDQELYY
|
|
|
|---|
| Component 2 |
| Name: | Potassium-transporting ATPase subunit beta |
|---|
| Synonyms: | ATP4B | ATP4B_HUMAN | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase subunit beta | Proton pump beta chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 33369.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | EBI_10719 |
|---|
| Residue: | 291 |
|---|
| Sequence: | MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
|
|
|
|---|
| BDBM50367961 |
|---|
| n/a |
|---|
| Name | BDBM50367961 |
|---|
| Synonyms: | CHEMBL1203526 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19N5S |
|---|
| Mol. Mass. | 361.463 |
|---|
| SMILES | Cc1cccc2c(c[nH]c12)-c1csc(N=C(N)NCc2ccccc2)n1 |w:14.15| |
|---|
| Structure | 
|
|---|
Search and Browse
