| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50015697 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209960 |
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| IC50 | 1000±n/a nM |
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| Citation |  McNamara, DJ; Berman, EM; Fry, DW; Werbel, LM Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines. J Med Chem33:2045-51 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYSY_MOUSE | Tyms |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34957.15 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1340097 |
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| Residue: | 307 |
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| Sequence: | MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
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| BDBM50015697 |
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| n/a |
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| Name | BDBM50015697 |
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| Synonyms: | 4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N,N-dimethyl-benzenesulfonamide | CHEMBL302669 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O3S |
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| Mol. Mass. | 411.477 |
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| SMILES | CN(C)S(=O)(=O)c1ccc(cc1)N(CC#C)Cc1ccc2nc(N)[nH]c(=O)c2c1 |
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| Structure | 
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