Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50010768 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201265 (CHEMBL873129) |
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IC50 | 11.0±n/a nM |
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Citation | Scherz, MW; Fialeix, M; Fischer, JB; Reddy, NL; Server, AC; Sonders, MS; Tester, BC; Weber, E; Wong, ST; Keana, JF Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor. J Med Chem33:2421-9 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50010768 |
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n/a |
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Name | BDBM50010768 |
Synonyms: | CHEMBL553535 | N,N'-Di-adamantan-1-yl-guanidine; hydrochloride |
Type | Small organic molecule |
Emp. Form. | C21H33N3 |
Mol. Mass. | 327.5068 |
SMILES | NC(NC12CC3CC(CC(C3)C1)C2)=NC12CC3CC(CC(C3)C1)C2 |w:13.16,TLB:6:7:11:5.4.10,17:18:22:16.15.21,21:16:23:20.22.19,21:20:23:16.15.17,THB:6:5:11:7.12.8,17:16:22:18.23.19,8:9:4:7.12.6,8:7:4:9.11.10| |
Structure |
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