Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50010748 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_201720 |
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IC50 | 15±n/a nM |
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Citation | Scherz, MW; Fialeix, M; Fischer, JB; Reddy, NL; Server, AC; Sonders, MS; Tester, BC; Weber, E; Wong, ST; Keana, JF Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor. J Med Chem33:2421-9 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50010748 |
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n/a |
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Name | BDBM50010748 |
Synonyms: | CHEMBL540291 | N-(3,5-Dimethyl-adamantan-1-yl)-N'-o-tolyl-guanidine; hydrochloride |
Type | Small organic molecule |
Emp. Form. | C20H29N3 |
Mol. Mass. | 311.4644 |
SMILES | Cc1ccccc1N=C(N)NC12CC3CC(C)(CC(C)(C3)C1)C2 |w:7.7,TLB:14:15:21:13.12.20,20:18:22:13.12.14,20:13:22:18.21.17,THB:19:18:22:13.12.14,16:15:21:13.12.20,14:13:21:15.22.17| |
Structure |
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