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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sigma non-opioid intracellular receptor 1 | ||
| Ligand | BDBM50010782 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_201720 | ||
| IC50 | 5.2±n/a nM | ||
| Citation |  Scherz, MW; Fialeix, M; Fischer, JB; Reddy, NL; Server, AC; Sonders, MS; Tester, BC; Weber, E; Wong, ST; Keana, JF Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor. J Med Chem33:2421-9 (1990) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sigma non-opioid intracellular receptor 1 | |||
| Name: | Sigma non-opioid intracellular receptor 1 | ||
| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 25124.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99720 | ||
| Residue: | 223 | ||
| Sequence: |
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| BDBM50010782 | |||
| n/a | |||
| Name | BDBM50010782 | ||
| Synonyms: | CHEMBL553347 | N-Adamantan-2-yl-N'-(2-iodo-phenyl)-guanidine; hydrochloride | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H22IN3 | ||
| Mol. Mass. | 395.2811 | ||
| SMILES | NC(Nc1ccccc1I)=NC1C2CC3CC(C2)CC1C3 |w:10.11,TLB:17:12:20:16.18.15,17:16:11.12.13:20,THB:15:14:11:16.17.18,15:16:11:14.13.20,TEB:10:11:14.13.20:16.17.18,10:11:20:16.18.15,10:11:18:14.20.15,(13.93,-.98,;13.93,-2.52,;15.28,-3.3,;16.62,-2.52,;16.62,-.98,;17.96,-.2,;19.3,-.98,;19.28,-2.52,;17.96,-3.3,;17.96,-4.84,;12.6,-3.3,;11.26,-2.52,;9.86,-1.94,;9.84,-.37,;10.89,.87,;9.55,.39,;9.55,-1.1,;8.36,-2.38,;10.87,-1.59,;12.29,-1.24,;12.29,.29,)| | ||
| Structure | 
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