| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
|---|
| Ligand | BDBM50010277 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_92451 (CHEMBL878705) |
|---|
| IC50 | 4500±n/a nM |
|---|
| Citation |  DuPriest, MT; Griffin, BW; Kuzmich, D; McNatt, LG Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors. J Med Chem34:3229-34 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B1 |
|---|
| Name: | Aldo-keto reductase family 1 member B1 |
|---|
| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35797.87 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1512484 |
|---|
| Residue: | 316 |
|---|
| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
|
|
|
|---|
| BDBM50010277 |
|---|
| n/a |
|---|
| Name | BDBM50010277 |
|---|
| Synonyms: | CHEMBL110661 | Spiro[9H-fluorene-9,4'-isothiazolidin]-3'-one 1',1'-Dioxide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H11NO3S |
|---|
| Mol. Mass. | 285.318 |
|---|
| SMILES | O=C1NS(=O)(=O)CC11c2ccccc2-c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
