| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50010041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_61769 |
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| IC50 | 41±n/a nM |
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| Citation |  Malleron, JL; Comte, MT; Gueremy, C; Peyronel, JF; Truchon, A; Blanchard, JC; Doble, A; Piot, O; Zundel, JL; Huon, C Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. J Med Chem34:2477-83 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 50931.60 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P61169 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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| BDBM50010041 |
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| n/a |
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| Name | BDBM50010041 |
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| Synonyms: | CHEMBL84087 | {1-[3-(1,1-Dioxo-1H-1lambda*6*-naphtho[1,8-cd]isothiazol-2-yl)-propyl]-piperidin-4-yl}-(4-fluoro-phenyl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25FN2O3S |
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| Mol. Mass. | 452.541 |
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| SMILES | Fc1ccc(cc1)C(=O)C1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1 |
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| Structure | 
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