| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
|---|
| Ligand | BDBM50453091 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_61992 |
|---|
| IC50 | 1.8±n/a nM |
|---|
| Citation |  Carroll, FI; Gao, YG; Rahman, MA; Abraham, P; Parham, K; Lewin, AH; Boja, JW; Kuhar, MJ Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters. J Med Chem34:2719-25 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent dopamine transporter |
|---|
| Name: | Sodium-dependent dopamine transporter |
|---|
| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 68749.45 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P23977 |
|---|
| Residue: | 619 |
|---|
| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
|
|
|
|---|
| BDBM50453091 |
|---|
| n/a |
|---|
| Name | BDBM50453091 |
|---|
| Synonyms: | CHEMBL2310929 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H20BrNO2 |
|---|
| Mol. Mass. | 338.24 |
|---|
| SMILES | [H][C@@]12CCC(C([C@@H](C1)c1ccc(Br)cc1)C(=O)OC)N2C |r,TLB:8:6:3.2:19,THB:15:5:3.2:19| |
|---|
| Structure | 
|
|---|
Search and Browse
