| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50002120 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_218827 (CHEMBL823938) |
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| IC50 | 2200±n/a nM |
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| Citation |  Diurno, MV; Mazzoni, O; Piscopo, E; Calignano, A; Giordano, F; Bolognese, A Synthesis and antihistaminic activity of some thiazolidin-4-ones. J Med Chem35:2910-2 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50002120 |
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| n/a |
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| Name | BDBM50002120 |
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| Synonyms: | 2-(3-Chloro-phenyl)-3-(3-dimethylamino-propyl)-thiazolidin-4-one;hydrochloride | CHEMBL319829 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H19ClN2OS |
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| Mol. Mass. | 298.831 |
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| SMILES | CN(C)CCCN1C(SCC1=O)c1cccc(Cl)c1 |
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| Structure | 
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