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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Substance-P receptor | ||
| Ligand | BDBM50002373 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_208659 (CHEMBL813319) | ||
| IC50 | 50±n/a nM | ||
| Citation |  Venepalli, BR; Aimone, LD; Appell, KC; Bell, MR; Dority, JA; Goswami, R; Hall, PL; Kumar, V; Lawrence, KB; Logan, ME Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles. J Med Chem35:374-8 (1992) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Substance-P receptor | |||
| Name: | Substance-P receptor | ||
| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 46371.54 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. | ||
| Residue: | 407 | ||
| Sequence: |
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| BDBM50002373 | |||
| n/a | |||
| Name | BDBM50002373 | ||
| Synonyms: | 1-(1-ethynyl)-15a,17a-dimethyl-(1R,15aS,17aS)-2,3,3a,3b,4,5,5a,6,15,15a,15b,16,17,17a-tetradecahydro-1H-benzo[4,5]imidazo[2,1-b]cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-ol | 1-(1-ethynyl)-15a,17a-dimethyl-(1R,15aS,17aS)-2,3,3a,3b,4,5,5a,6,15,15a,15b,16,17,17a-tetradecahydro-1H-benzo[4,5]imidazo[2,1-b]cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-ol(0.2MH2O) | 1-(1-ethynyl)-15a,17a-dimethyl-(1R,15aS,17aS)-2,3,3a,3b,4,5,5a,6,15,15a,15b,16,17,17a-tetradecahydro-1H-benzo[4,5]imidazo[2,1-b]cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-ol(0.7MH2O) | CHEMBL333069 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H33N3O | ||
| Mol. Mass. | 439.5918 | ||
| SMILES | C[C@]12CCC3C(CCC4Cc5nc6nc7ccccc7n6cc5C[C@]34C)C1CC[C@@]2(O)C#C | ||
| Structure | 
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