Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A/2B/2C |
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Ligand | BDBM50002213 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_2126 |
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Ki | 3.6±n/a nM |
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Citation | Gilligan, PJ; Cain, GA; Christos, TE; Cook, L; Drummond, S; Johnson, AL; Kergaye, AA; McElroy, JF; Rohrbach, KW; Schmidt, WK Novel piperidine sigma receptor ligands as potential antipsychotic drugs. J Med Chem35:4344-61 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2A/2B/2C |
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Name: | 5-hydroxytryptamine receptor 2A/2B/2C |
Synonyms: | Serotonin 2 (5-HT2) receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 2124 |
Components: | This complex has 3 components. |
Component 1 |
Name: | 5-hydroxytryptamine receptor 2C |
Synonyms: | 5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2C_MOUSE | 5ht1c | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr1c | Htr2c | Serotonin 2c (5-HT2c) receptor |
Type: | Enzyme |
Mol. Mass.: | 51948.16 |
Organism: | Mus musculus (Mouse) |
Description: | P34968 |
Residue: | 459 |
Sequence: | MVNLGTAVRSLLVHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELRNISLNFLKCCCKKGDEEENAPNPNPDQKPRRKKKEKRPRGT
MQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYV
CSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHT
NERVVRKANDTEPGIEMQVENLELPVNPSNVVSERISSV
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Component 2 |
Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_MOUSE | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr2 | Htr2a | Serotonin 2a (5-HT2a) receptor |
Type: | Enzyme |
Mol. Mass.: | 52843.00 |
Organism: | Mus musculus (Mouse) |
Description: | P35363 |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYK
SSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
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Component 3 |
Name: | 5-hydroxytryptamine receptor 2B |
Synonyms: | 5-HT2 | 5-HT2B | 5-hydroxytryptamine receptor 2B | 5-hydroxytryptamine receptor 2B (5HT2B) | 5HT2B_MOUSE | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr2b |
Type: | Enzyme |
Mol. Mass.: | 53610.91 |
Organism: | Mus musculus (Mouse) |
Description: | Q02152 |
Residue: | 479 |
Sequence: | MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLI
LAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIW
PLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWL
ISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTI
HTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETL
MRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTL
LEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSM
VENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
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BDBM50002213 |
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n/a |
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Name | BDBM50002213 |
Synonyms: | 1-(4-Fluoro-phenyl)-2-{1-[2-(1H-indol-3-yl)-ethyl]-piperidin-4-yl}-ethanone;monohydrate | CHEMBL136064 |
Type | Small organic molecule |
Emp. Form. | C23H25FN2O |
Mol. Mass. | 364.4558 |
SMILES | Fc1ccc(cc1)C(=O)CC1CCN(CCc2c[nH]c3ccccc23)CC1 |
Structure |
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