| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM50000056 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_154415 |
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| IC50 | 21000±n/a nM |
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| Citation |  Coates, WJ; Connolly, B; Dhanak, D; Flynn, ST; Worby, A Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. J Med Chem36:1387-92 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Type: | Protein |
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| Mol. Mass.: | 99975.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76074 |
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| Residue: | 875 |
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| Sequence: | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
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| BDBM50000056 |
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| n/a |
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| Name | BDBM50000056 |
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| Synonyms: | (sulmazole)2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine | 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine | 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine (sulmazole) | 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine(sulmazole) | 2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine | 2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile | CHEMBL286020 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N3O2S |
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| Mol. Mass. | 287.337 |
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| SMILES | COc1cc(ccc1-c1nc2ncccc2[nH]1)S(C)=O |
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| Structure | 
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