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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sigma non-opioid intracellular receptor 1 | ||
| Ligand | BDBM50044715 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_201723 | ||
| Ki | 80±n/a nM | ||
| Citation |  de Costa, BR; He, XS; Linders, JT; Dominguez, C; Gu, ZQ; Williams, W; Bowen, WD Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds. J Med Chem36:2311-20 (1993) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sigma non-opioid intracellular receptor 1 | |||
| Name: | Sigma non-opioid intracellular receptor 1 | ||
| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 25124.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99720 | ||
| Residue: | 223 | ||
| Sequence: |
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| BDBM50044715 | |||
| n/a | |||
| Name | BDBM50044715 | ||
| Synonyms: | (1-Aza-bicyclo[2.2.2]oct-3-yl)-[2-(3,4-dichloro-phenyl)-ethyl]-methyl-amine | CHEMBL75300 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H22Cl2N2 | ||
| Mol. Mass. | 313.265 | ||
| SMILES | CN(CCc1ccc(Cl)c(Cl)c1)C1CN2CCC1CC2 |TLB:1:12:16.15:18.19,(9.5,-4.98,;9.5,-3.44,;10.82,-2.67,;12.17,-3.44,;12.17,-4.98,;13.49,-5.74,;13.51,-7.28,;12.17,-8.06,;12.16,-9.6,;10.82,-7.29,;9.5,-8.05,;10.82,-5.75,;9.19,-2.05,;9.99,-.91,;8.45,.02,;6.74,-.75,;5.95,-1.97,;7.61,-1.1,;7.61,.28,;8.44,1.11,)| | ||
| Structure | 
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