| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thromboxane-A synthase |
|---|
| Ligand | BDBM50045943 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_213089 |
|---|
| IC50 | 270±n/a nM |
|---|
| Citation |  Cozzi, P; Carganico, G; Fusar, D; Grossoni, M; Menichincheri, M; Pinciroli, V; Tonani, R; Vaghi, F; Salvati, P Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition. J Med Chem36:2964-72 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thromboxane-A synthase |
|---|
| Name: | Thromboxane-A synthase |
|---|
| Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 59971.80 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_209768 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
|
|
|
|---|
| BDBM50045943 |
|---|
| n/a |
|---|
| Name | BDBM50045943 |
|---|
| Synonyms: | 4-(3-Imidazol-1-yl-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | CHEMBL323095 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N3O4 |
|---|
| Mol. Mass. | 367.3984 |
|---|
| SMILES | COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1cccc(c1)-n1ccnc1 |c:13,t:10| |
|---|
| Structure | 
|
|---|
Search and Browse
