| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50045952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_213089 |
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| IC50 | 260±n/a nM |
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| Citation |  Cozzi, P; Carganico, G; Fusar, D; Grossoni, M; Menichincheri, M; Pinciroli, V; Tonani, R; Vaghi, F; Salvati, P Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition. J Med Chem36:2964-72 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59971.80 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_209768 |
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| Residue: | 533 |
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| Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
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| BDBM50045952 |
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| n/a |
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| Name | BDBM50045952 |
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| Synonyms: | 5-Acetyl-4-(3-imidazol-1-yl-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester | CHEMBL100671 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O3 |
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| Mol. Mass. | 351.399 |
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| SMILES | COC(=O)C1=C(C)N=C(C)C(C1c1cccc(c1)-n1ccnc1)C(C)=O |c:4,t:7| |
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| Structure | 
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