Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetInositol polyphosphate-5-phosphatase A
LigandBDBM50046072
Substrate/Competitorn/a
Meas. Tech.ChEBML_4316
Ki 535000±n/a nM
Citation Kozikowski, AP; Ognyanov, VI; Chen, C; Fauq, AH; Safrany, ST; Wilcox, RA; Nahorski, SR Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor. J Med Chem36:3035-8 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Inositol polyphosphate-5-phosphatase A
Name:Inositol polyphosphate-5-phosphatase A
Synonyms:5PTASE | I5P1_HUMAN | INPP5A | Type I inositol-1,4,5-trisphosphate 5-phosphatase
Type:PROTEIN
Mol. Mass.:47823.52
Organism:Homo sapiens (Human)
Description:ChEMBL_4316
Residue:412
Sequence:
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN
YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF
DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL
VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK
SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT
ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL
VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50046072
n/a
NameBDBM50046072
Synonyms:(1R,2R,4R)-Cyclohexane-1,2,4-tris (methylenephosphonate)
TypeSmall organic molecule
Emp. Form.C9H15O9P3
Mol. Mass.360.1346
SMILES[O-]P([O-])(=O)CC1CCC(CP([O-])([O-])=O)[C@H](CP([O-])([O-])=O)C1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: