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TargetMultidrug transporter MdfA
LigandBDBM55038
Substrate/Competitorn/a
Meas. Tech.ChEMBL_68323 (CHEMBL680694)
IC50 2500±n/a nM
Citation Nelson, ML; Park, BH; Andrews, JS; Georgian, VA; Thomas, RC; Levy, SB Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines. J Med Chem36:370-7 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Multidrug transporter MdfA
Name:Multidrug transporter MdfA
Synonyms:Chloramphenicol resistance pump cmr | MDFA_ECOLI | Multidrug translocase mdfA | cmlA | cmr | mdfA
Type:PROTEIN
Mol. Mass.:44327.48
Organism:Escherichia coli (strain K12)
Description:ChEMBL_68323
Residue:410
Sequence:
MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTA
YLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLC
FIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAAL
AAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIA
QSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLL
VAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLI
FTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG
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  Blast E-value cutoff:
BDBM55038
n/a
NameBDBM55038
Synonyms:(2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (2E,4S,4aR,5S,5aR,12aS)-2-[azanyl(oxidanyl)methylidene]-4-(dimethylamino)-6-methylidene-5,10,11,12a-tetrakis(oxidanyl)-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (4S,4aR,5S,5aR,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-3,12-diketo-6-methylene-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride | (4S,4aR,5S,5aS,12aS)-4-(dimethylamino)-5,10,12a-trihydroxy-1,3,11,12-tetraketo-6-methylene-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride | MLS001049011 | Methacycline | SMR000387056 | cid_16196941
TypeSmall organic molecule
Emp. Form.C22H22N2O8
Mol. Mass.442.4187
SMILESCN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(C(=O)c4c(O)cccc4C3=C)C(=O)[C@]2(O)C(=O)C(C(N)=O)C1=O
Structure
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