Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM29568 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_138892 (CHEMBL747884) |
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Ki | 0.20±n/a nM |
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Citation | Zuckermann, RN; Martin, EJ; Spellmeyer, DC; Stauber, GB; Shoemaker, KR; Kerr, JM; Figliozzi, GM; Goff, DA; Siani, MA; Simon, RJ Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library. J Med Chem37:2678-85 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM29568 |
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n/a |
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Name | BDBM29568 |
Synonyms: | CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]-Furazosin | [3H]-Minipress | [3H]-Pratsiol | [3H]-Prazosin |
Type | radiolabeled ligand |
Emp. Form. | C19H21N5O4 |
Mol. Mass. | 383.4011 |
SMILES | COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 |
Structure |
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