Reaction Details |
| Report a problem with these data |
Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
---|
Ligand | BDBM50368782 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_202882 (CHEMBL810000) |
---|
IC50 | 1750±n/a nM |
---|
Citation | Bakshi, RK; Patel, GF; Rasmusson, GH; Baginsky, WF; Cimis, G; Ellsworth, K; Chang, B; Bull, H; Tolman, RL; Harris, GS 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem37:3871-4 (1994) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
---|
Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase |
Type: | Enzyme |
Mol. Mass.: | 28406.59 |
Organism: | Homo sapiens (Human) |
Description: | P31213 |
Residue: | 254 |
Sequence: | MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
|
|
|
BDBM50368782 |
---|
n/a |
---|
Name | BDBM50368782 |
Synonyms: | Bexlosteride | CHEMBL24955 | LY-191704 |
Type | Small organic molecule |
Emp. Form. | C14H16ClNO |
Mol. Mass. | 249.736 |
SMILES | CN1[C@@H]2CCc3cc(Cl)ccc3[C@H]2CCC1=O |
Structure |
|