| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Ligand | BDBM50037922 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205213 (CHEMBL816487) |
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| IC50 | 3.3±n/a nM |
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| Citation |  Bakshi, RK; Patel, GF; Rasmusson, GH; Baginsky, WF; Cimis, G; Ellsworth, K; Chang, B; Bull, H; Tolman, RL; Harris, GS 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem37:3871-4 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29472.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18405 |
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| Residue: | 259 |
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| Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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| BDBM50037922 |
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| n/a |
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| Name | BDBM50037922 |
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| Synonyms: | (4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-1-ethyl-4a,6a,10-trimethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | CHEMBL340305 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H51NO |
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| Mol. Mass. | 429.7213 |
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| SMILES | CCN1C2C[C@H](C)C3C4CCC(C(C)CCCC(C)C)[C@@]4(C)CCC3[C@@]2(C)CCC1=O |
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| Structure | 
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