| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50037980 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_208319 (CHEMBL812837) |
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| Ki | 93±n/a nM |
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| Citation |  Hilpert, K; Ackermann, J; Banner, DW; Gast, A; Gubernator, K; Hadváry, P; Labler, L; Müller, K; Schmid, G; Tschopp, TB Design and synthesis of potent and highly selective thrombin inhibitors. J Med Chem37:3889-901 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50037980 |
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| n/a |
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| Name | BDBM50037980 |
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| Synonyms: | 1-[(S)-3-[(1-Carbamimidoyl-piperidin-3-ylmethyl)-carbamoyl]-2-(naphthalene-2-sulfonylamino)-propionyl]-piperidine-4-carboxylic acid ethyl ester; hydrochloride | CHEMBL543183 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H40N6O6S |
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| Mol. Mass. | 600.729 |
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| SMILES | CCOC(=O)C1CCN(CC1)C(=O)[C@H](CC(=O)NCC1CCCN(C1)C(N)=N)NS(=O)(=O)c1ccc2ccccc2c1 |
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| Structure | 
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